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DTSTART;TZID=UTC:20161214T123000
DTEND;TZID=UTC:20161214T133000
DTSTAMP:20161122T114051Z
CREATED:20161101T145416Z
LAST-MODIFIED:20161122T114051Z
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SUMMARY:Seminar – Modelling cardiovascular and metabolic disease using transgenic zebrafish – Dr Marcel den Hoed
DESCRIPTION:All are invited to the CEDAR/MRC Epidemiology Seminar: \nModelling cardiovascular and metabolic disease using transgenic zebrafish\n\nDr Marcel den Hoed\, Department of Medical Sciences\, Molecular Epidemiology and SciLifeLab\, Uppsala University.\n\nMeeting Rooms 1&2\, Level 4\, Institute of Metabolic Science\, Cambridge Biomedical Campus\nAbstract\nGenome-wide association studies identified hundreds of loci that are associated with cardiometabolic diseases and risk factors. For most loci the causal genes remain unknown. My group developed experimental pipelines that facilitate image-based genetic screens in zebrafish larvae by using: 1) the zebrafish’ well-annotated genome; 2) CRISPR-Cas9 based mutagenesis; 3) fluorescent transgenes and dyes; 4) automated positioning and imaging technologies; 5) custom-written image quantification pipelines. Results from dietary\, drug and genetic screens confirm that zebrafish larvae represent an opportunity to identify causal genes for cardiometabolic diseases and risk factors\, and increase our understanding of disease aetiology. \nAbout Dr den Hoed\nMarcel den Hoed completed his PhD on genetic and physiological aspects of physical activity and food intake regulation at Maastricht University (Netherlands) in 2009. He was then awarded a three-year Career Development Fellowship at the MRC Epidemiology Unit\, where he initiated and coordinated genome-wide association studies for heart rate and physical activity\, supervised by Ruth Loos. In 2012 he started a second post-doc at the Karolinska Institutet (Sweden)\, before initiating his own group at Uppsala University (Sweden) in 2013. His current research aims to translate GWAS findings into clinically relevant results using high-throughput genes in live transgenic zebrafish model systems. \nSign up for future seminars\n[gravityform id=”1″ name=”CEDAR/MRC Epidemiology Seminar Series sign-up” title=”false”]
URL:https://www.epi.ims.cam.ac.uk/event/seminar-14-december-2016-dr-marcel-den-hoed/
LOCATION:Meeting rooms\, Level 4 Institute of Metabolic Science\, Addenbrooke’s Treatment Centre (ATC)\, Cambridge Biomedical Campus\, Cambridge\, CB2 0SL\, United Kingdom
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